V. H. home - Věda: Granty - Učení - Osobní
| Principal Investigator | Title | Provider | Reg. # | Years | |
|---|---|---|---|---|---|
| Hampl | Dynamics and mechanisms of the chronic hypoxia-induced alterations in pulmonary and placental circulations | GACR | 305/05/0672 | 2005-2007 | Chronic hypoxia is a major and clinically important factor in the development of chronic pulmonary hypertension, a severely disabling disorder with high mortality and poor treatment options. While hypoxia-induced morphological remodeling of the vascular wall clearly plays a role, the participation of sustained hypoxic vasoconstriction (induced by chronic hypoxia but not readily reversible upon reoxygenation) is not well understood. We will quantify the contribution of this phenomenon in the development of chronic hypoxic pulmonary hypertension and test several of its possible mechanisms. In addition, parallel studies will also be carried with the other mammalial organ specialized for blood oxygenation, the placenta (where changes analogous to chronic hypoxic pulmonary hypertension are frequently assumed but were never proved), after characterizing for the first time the exact effects of chronic hypoxia on the fetoplacental vascular bed. Understanding the mechanisms of the effects of chronic hypoxia on the vessels of both organs specialized for blood oxygenation is a prerequisite for future causal breakthroughs in therapy of several major neonatal and adult disorders. |
| Hampl | Patophysiology of the effects of chronic hypoxia on the fetoplacental vascular bed | GAUK | 82/2004/C | 2004-2006 | |
| Klescova | Morphology of the fetoplacental vascular bed under the influence of chronic hypoxia | GAUK | 53/2005/C |
2005-2006 | |
| Ostadal | Cardiovascular Research Centre | MSMT | 1M6798582302 |
2005-2007 |